The Detox has begun , Homotoxicology Part 2

So , what have we seen thus far you ask?!

As you all know, this past August (2013) we have come to a 
point in Bella's journey where detoxing was the next path 
seemingly to take from this road we are traveling. 
Like what was mentioned in our first post 
Homotoxicology  Let the Detox begin!  
this was the path we choose to take from all those available out there. 
I felt more comfortable trying the natural approach and thus far, to my delight, it has been working !!

The first protocol went well. The behaviors that MC said would happen did. She is truly quite amazing with what to expect! It also helps me so 
much as I then know whats 'normal" and when it might be an issue to call. Bella made it through the first round well. Then we had our 
second appointment in October (2013). When we returned, Bella 
was tested with MC's computer again, and new readings came up. 
It was all POSITIVE news! MC was delighted to see her readings come 
in so well. MC states Bina's body is doing what its supposed to be doing, and how pleased she was that her body was responding so well. We received our second protocol along with the "what to expect' list and off we went.This is when we really just started to see a glimpse of what was in store ahead. 
Protocol 2
Again, she started out fine and then the "Autism" reared its ugly head here and there. Showing itself they way MC stated. Through anger, frustration and emotional outbursts for no reason here and there. I was sure to keep an eye on her bowel movements as that is so important. This time around she definitely urinated and pooped alot more. She didn't get "backed up" but one time which Oxypowder help alleviate.
Besides that her potty issues were under control. (phew)The first few weeks were bumpy as expected, and towards the last 2 before our most recent and 3rd appointment some truly amazing things started to happen. Bella's verbality communication cognitively, expressively , receptively opened up even MORE so.. 
She became more involved in joining discussions, helping out in school, retaining information and VERBALLY expressing it HUGE things, 
stuff we have not seen before. 
She was showing and talking so much about how she feels about something, where before you wouldn't get a response.. or a verbal response I should really say. She was now responding with much less delay (1-3 second) and verbally responding appropriately! 
One of many that stand out is our Toy Story 3 ABC family movie night. You know, Christmas time they have a list of movies ..
countdown to Christmas?! Ring a bell? ok...
Well it was Toy Story marathon day. She was watching it. 
I was in an out as I was cleaning up and getting ready for dinner.

She LOVES the movies and gets a kick out of the fact that when the children leave , the toys come alive. (I really do think she believe thats what happens when she goes to school with her jewelpets lol) anyways, 
Toy story 2 was on when I walked in the room and Woody's up on a shelf full of dust, sad. 
Since I saw, I then asked sabrina
"oh no, Woody looks sad, what happened? " (hoping for a response)
to my pleasant surprise She immediately replied
" Woody's arm is ripped, no play!" 
Oh no poor Woody I said... 

"ya he is sad mommy"... 
"Well I hope he feels better soon"....
I was so happy to see her answering more and more complex questions.. 

I look at this as Auditory Comprehension. 

(APD is an issue with Bina as it is with ALL ASD kids) 

which is very important for me to see and know she is processing all her information auditory . She was watching the movie and retaining the storyline following it and now able to be more verbally responsive/expressive !! FUA!!!
THEN...

Toy Story part 3 came on next. The Barbie in this one I personally got a kick out of, I shared with Bella how I had that SAME barbie, outfit and all! I went on and told Bella...

"This Barbie was my favorite because she was the first real flexible Barbie and I could make her do splits and kicks like dance moves. I was 10 years old when I had that Barbie, she was so cool! "

Bella smiled and giggled and then I left the 

room to continue on what I was doing.

Then later on in the movie, I went into the den to see what was happening , my eldest daughter had joined Bella earlier watching it together at that point. The Barbie came on, so casually told my 

teen laughing, "I had that same doll" 
then 

Bella joined the conversation!!! 

"Mommy was 10 years old! Its her most favorite dance Barbie!"

I immediately locked eyes with my teen , then looked at B...
YES! Thats right! Thanks for telling sister that! !
Now she HAS responded right away before, here and there..

but NOT like this...

This was a true display of whats improving..
This was HUGE for us!

We spoke about the doll at the beginning of the movie, 

and it was almost over when my teen arrived. 
Nothing was mentioned 

again in between..

so for her to do this... 

this was all natural responding..

this was Awesome! 
Now THAT is recovery working at its finest! 

Things such as that have been happening, and I couldn't be more pleased! 
So this takes us to our 3rd and most recent appointment, earlier in this month. 
I shared this experience as one of many that Bella has displayed with MC. Bella was again hooked up and tested by this computer MC uses and again the readings came out GREAT! MC was happy and so were we all!  Now these readings indicated that her body is definitely working in the way we hoped. 
And now this next protocol is where its going to get tricky. 
MC says its time to start going inter-cellular. 
Basically what we have been doing thus far is preparing her body for "combat" 
we have been giving her body the tools and support it needs ( according to her individualized readings) so her body can naturally do what its designed and meant to do. This will continue to help support her systems to aide her body in getting all this junk out! MC feels we are ready to start the next step, so here we go! I do have to say I am nervous, Bella has been doing so well , and I dont want to see it all go away again. But I know this is what we have to do, as its part of the process.  
I know my baby will come out of this even better and stronger. 
Thats my motivation..SEEING this is helping me trust the process even MORE then I already did. I am listening to my gut unlike the past. So I know we are on the right track 

We have started the new  protocol 2 weeks ago, and here is the new list of "what to expect". We start inter-cellular which basically means we are going in deep and pulling out what we can on the cellular level. Thats what I like about homeotoxicology is that I can slow it up or go faster..I let her body guide me, I use it for cues. Like today I will do alittle slower by doing a few drops on wrist then some orally instead all orally because she has been displaying some emotional outbursts. .
It seams tricky but I am getting the hang of it.. 
I just get so sad when she gets sad emotional upset...
like over pinkiepies hair being in the wrong place, where otherwise it wouldnt matter..stuff like that. 
But to fight this we have to push through and the Autism comes out as we fight and in doing so, 
once we get down the road, 
more of WHO Bella really is breaks and shines through...
and that is the reward. 
Seeing the results after the storm passes.


So here we go! Wish us luck and please keep sending those prayers!
Next appointment is in February. I guess we shall see what happens till then! 


  

Nrf2 Protandim Oxidative Stress and Autism

One of many new things I have learned on this journey is that, there is ALWAYS something NEW to learn! I mean back in March when I got B's test results one big thing was the oxidative stress ... it was off the charts
I was like, what the heck does THAT mean?!

Oxidative stress reflects an imbalance between the systemic manifestation of reactive oxygen species and a biological system's ability to readily detoxify the reactive intermediates or to repair the resulting damage. Disturbances in the normal redox state of cells can cause toxic effects through the production of peroxides and free radicals that damage all components of the cell, including proteins,lipids, and DNA. Further, some reactive oxidative species act as cellular messengers in redox signaling. Thus, oxidative stress can cause disruptions in normal mechanisms of cellular signaling.
In humans, oxidative stress is thought to be involved in the development of cancer,^[1] Parkinson's disease, Alzheimer's disease,^[2]atherosclerosis, heart failure,^[3] myocardial infarction,^[4][5] fragile X syndrome,^[6] Sickle Cell Disease,^[7] lichen planus,^[8] vitiligo,^[9]autism,^[10] and chronic fatigue syndrome.^[11] However, reactive oxygen species can be beneficial, as they are used by the immune system as a way to attack and kill pathogens.^[12] Short-term oxidative stress may also be important in prevention of aging by induction of a process named mitohormesis.^[13]

So basically MORE inflammation on a cellular level that damages cells , impairs the cell's ability to heal itself , damages the ability to detoxify by damaging  the body's glutathirone  . Isn't that seemingly the case with everything? 
The Brain ....inflammation / cell damage
The Gut ..... inflammation / cell damage 
The immune system ...   their WHOLE body is inflamed! 
These poor kids! 
Now you wonder why some bang their heads, bite ,hit ,cry...they are in PAIN! 
SEVERE Pain! Between all these areas being hit, and when left UNTREATED 
they will continue to digress, their health , their behaviors , their lives...
you have to TREAT the insides , to heal them to help them recover....
* Finding the imbalances and treating them...
This is ONE piece of that puzzle to definitely speak to your DAN / MAPS doc about!
....OK....
So Now we know what this is, HOW do we help it?! What can we do about this?!
Well I have learned about a great product, that our MAPS doc added to Bella's protocol. We have been using it since March. 
Its called Nrf2 Pathway Activator  or Protandim.

And real quick, by NO MEANS is this is sale thing..
this is a SHARING INFO thing! I'm not a sales lady! lol
Ok..lets proceed...
Nrf2 and Protandim are the same in one, figure to clear that as I was confused at first. The difference is simply a name. 
Protandim activates Nrf2, which communicates with cells, instructing them to do what they’re already designed to do: up-regulate “survival genes,” genes that enable cells to survive in the face of stress from free radicals and other oxidants, and down-regulate other genes to help the body function at an optimal level. So its designed to relief oxidative stress! BINGO! 
I was on board to try it! The first few months I tried the brand my doc gave me, then I came across this brand, 
Life Vantage and then I learned that they have been helping many with Autism so I wanted to learn more. A mother reached out to me about How it helped her non-verbal son so much he began to try and speak! And now has a few words and keeps trying to get more out daily! That made my heart sing for her boy , and my Hope for Bina go up higher... I did send the info to our MAPS doc, and asked his opinion about trying this brand, and he checked it out and gave his approval  to try it if i'd like. So we did! We have been using this brand since this past August , and honestly seams no different...the only difference is pricing, and pill amount  and type. The Nrf2 by IP ( other brand ) was a capsule and 2 caps was 1 serving. This brand is a little smaller pill and only 1 is needed daily. 
Also, the Protandim is slightly cheaper which helps in regards to all the other things we need to get for her, so I am sticking with Life Advantage for now. Bella seams alot less anxious happier, more relaxed and calmer in situations in which she would otherwise not be. She has shown better concentration and improved academics and behavior at school. It seams to help relieve something..and I am guessing what they called the "oxidative stress". And now since we started the detoxing, this will aide in that so its a double wammie of positiveness for us. I give it a warrior Mom's thumb up!  
Life Advantage Protandim
Whats the ingredients? 

• Calcium
  Milk Thistle Extract seed 
  Bacopa Extract whole herb 
  Ashwagandha Extract root 
  Green Tea Extract leaf 
  Tumeric Extract rhizome
• Other ingredients: Microcrystalline Cellulose, Croscarmellose Sodium,Silica, Modified Cellulose, Stearic Acid, magnesium Stearate, maltodextrin, Medium Chain Triglycerides.
  
  
• 100 % Vegetarian-Free of Gluten, Wheat, Dairy, Soy, Gelatin and yeast
  
  

Great info and Articles : 

Autism, Oxidative Stress, and Protandim

DNA Animation Protandim Repair Prevent Damage 

Protandim Scientific Review - Autism

Homotoxicology .... Let the Detox begin!!

Homotoxicology?! WHAT is that?!

Many have heard of homeopathy , but it seams that when you use the words homotoxicology or homotoxicologist, people are more unaware about who they are and what they do. I am hoping to help everyone out with that question....
So what exactly IS homotoxicology you ask?

Homotoxicology is a modern extension of homeopathy developed partly in response to the effects of the Industrial Revolution, which imposed chemical pollutants on the human body. Homotoxicology and homeopathy stress the importance of stimulating the body's natural ability to fight disease and the use of naturally derived formulas to aid the healing process.

Dr. Samuel Hahnemann, a German chemist and physician, developed homeopathy over 200 years ago as a natural form of medicine based on the Law of Similarities, which basically states that “likes cure likes.” In other words, if a substance that creates symptoms of a disease in a healthy person is given in the proper measure to a sick person, it can help stimulate the body's natural defense mechanisms. An example of this is coffee, which under some circumstances and when administered in the right dosages, has been found to be helpful in treating insomnia. Homeopathy is used to fight existing conditions and help strengthen the immune system. 

Homotoxicology Treatments

Homotoxicology employs antihomotoxic formulations that stimulate the body's detoxifying functions. Depending on the phase of the disease and other factors, conventional medical treatments may be advised. In many cases, both conventional and homeopathic treatments will be indicated.

Homotoxicology also emphasizes the importance of a healthy diet and lifestyle. In particular, it stresses the damage that can be done by living in a polluted environment and the ingestion of foods that have been treated with pesticides. Remedies prescribed by practitioners include natural substances designed to help the body excrete built up chemical toxins.

Resource more Info: http://www.naturaltherapypages.com.au/article/what_is_homotoxicology#ixzz2aS3Jl3Pb

Homotoxicology pursues an indication-based approach, i.e., there is a remedy based on the syndrome or indication of the patient. Most anti-homotoxic preparations contain complexes of remedies in the low to middle ranges of dilution. Each preparation carries an indication, facilitating its use, so there is no need to determine the individual remedy choice from the repertory or the potency. Using conventional medicine indications connects anti-homotoxic with allopathy while its use of potentized substances unites it with homeopathy, thereby making the connecting link between conventional (allopathic) medicine and homeopathy.

Homotoxins (human-toxins) include all of those substances (chemical or biochemical) and non-material influences which can cause illness in humans. Their appearance results in regulation disorders in the organism. Every illness is due to their effects. Homotoxins may be introduced from the exterior (exogenous) or from the body itself (endogenous).

Homotoxicosis is a non-physiological condition which arises after reaction of a homotoxin on cells and tissues. This occurs as a humoral or cellular phenomenon and can be followed by morphological alterations on tissues. The specific homotoxicosis is named after the homotoxin which triggers it and leads to defensive measures by the organism whose goal is the elimination of the homotoxins and restoration of the physiological conditions when possible, i.e., return to balance.

Healing occurs following the principles of Hering's Law of Cures, i.e.:

• From top to bottom
• From inside to outside
• From organs of major importance to those of lesser importance and
• In reverse chronological order

Homotoxicological medicines have been developed to serve the very specific purpose of restoring regulation in the body. Rather than being a single remedy, they are complex homeopathic compositions that incorporate various dilutions of remedies, as well as potentized catalysts, allopathics and vitamins. Single remedies often induce a "healing crisis". The combination of remedies within the anit-homotoxic formulas modifies this process. This topic is quite complex and I highly recommend that when you set up an account with Heel, Inc., you attend their free seminars in which homotoxicology is discussed in greater depth.

Resource more info: http://www.fourgatesorientalmedicine.com/homo.php

Mary Coyle from the Real child center located in 
NYC has been known and well respected throughout the Autism community. 
She has been practicing for over 20 years after helping her own ASD son recover, she continues helping many other kids like my child. After seeing her speak at a local 
TACA (Talk About Curing Autism) Chapter meeting earlier this year and after speaking with countless parents whom have used and are using her to treat their autistic children they have had nothing but great things to say about her AND about the positive effects and gains they had seen happen for their children. 
She has also presented at Autism One conference in 2009. 
See her presentation here. 
I knew we were up to the 'detox' point in our journey, 
and I know there are many ways to go about this such as chelation (oral or IV) or the Andy Cutler protocol. But after learning exactly what homotoxicology was and learning it was the least invasive way, easy on the immune system , AND having all these awesome referrals it was simply a "no brainier for us. 
It was just a matter of time until we were able to save up to bring her and 
start our new journey....detoxing.

I was super excited and anxious about what awaited us. We took a family trip into the city , we don't go there much and haven't been able to spend some time together so opportunity arose...we jump! 
It took us no time really to get there. Traffic on a Sunday wasn't bad until we go to the Lincoln Tunnel which apparently had only one lane open due to renovations so that was abit of a mess, but her office isn't that far away once you cross into NYC it really wasn't that bad. We found her office , parked and headed on inside!                                                                                                                                                                                                                                                                                                                                                                                        

We arrived alittle early so Bina just played with the toys while we waited. 

 

Then it was our turn. Meeting Mary again was so nice. She has a warm smile and a very caring presence about her. She took her time. Spoke with me about Bella before and after the injury. About when I figured out everything and what we have done to this point. Where she was, been and at now. After getting all Bella's info she explained alittle more about what it was she does, and more about what homotoxicology was. And when she was done it was time to test and see what Bella's body was at, what the readings were going to be. 

She had Bella hold this rod, then had this pen like tool that she would dip in water then touch certain points on her hands and her feet. When she did this the computer would take readings and 'make music' showing all sorts of information about all sorts of different things. It does not hurt at all. When she does this it tells her what was going on with her energy levels as they relate to her adrenals, her liver, kidneys, inflammation,  gut , allergies...
all sorts of stuff. It really was cool to watch. 
After she was done Mary was really overall happy with Bina's readings. There are areas of work needed obviously, but she was showing to be in a better place then expected. Thats what made us both happy. She got together what Bella's starting protocol was and explained how to implement it.

Basically she starts with supporting the organs first and opening pathways. Then as we proceed to start giving her body signals to assist in removing specific toxins like heavy metals and pathogens such as parasites. 
She wrote everything down and told us what to expect with each bottle. There was 3 in there that may make her "angry"  at first. so this will be interesting to see and watch. She explained I can start out slow or go for it all completely. It was up to me what speed I wanted to go, and up to Bella's body on how she handles it all. 
I am thinking to start off "medium" lol in-between  the real question is when. She has a week and half then summer school ends. Should I start this week? or wait until its over? I am not entirely sure yet. But one thing I am sure about is that this is going to be a ride. As Mary says...it will be up and down, but through every storm there is a rainbow...and when this is all said and done I know my Bella will be in a Much better place biologically and thats what really matter the most! 
We return back to her in 8 weeks! Wish us Luck! 

The Detox has begun , Homeotoxicology Part 2

What is Methyl B12 and what exactly can it do for my ASD child?

Methyl B-12 , I am sure alot of you have heard about it. 
It has become well known throughout the Autism community as we are finding out more and more that these kids are showing some sort of methylation issues. Weather it came up from a blood test showing lack of vitamin B12 or that the child showed some level of the mutated MTHFR gene, what remains in common is that they are deficient in something in the body for whatever reason, weather created or else-wise  that will not allow there bodies to properly methylate produce correct cells and detoxify. SO then what can we do to help? Thats where Methyal B-12 comes into play.


What is Methyl-B12 (B12)?  

by: DR. SONYA DOHERTY, ND 

B12 (cobalamin) is a vitamin “family” with five unique family members that each do different things.  Out of the B12 family, only methyl-B12 has the ability to activate the methionine/homocysteine biochemical pathway directly which results in more “fuel” to the brain.

B12 works with folic acid to make all the cells in the body.  It plays a key role in methylation.  Methylation makes ALL of the cells in our body.  It is the process of adding genetic material to cells.  After conception, the cells in the womb that will later become the fetus are DEMETHYLATED.  The process of development depends on methylation.

Increasing evidence is revealing the role of methylation in the interaction of environmental factors with genetic expression in playing a role in developmental issues like autism and ADHD.  Differences in maternal care during the first 6 days of life in a mammal can cause different methylation patterns in some genes.  Methylation has also been shown to impact inflammation after a child leaves the womb.  We know that autism and ADHD are linked to inflammation.  Now we are discovering that inflammation, autism and ADHD are linked to impaired methylation.

Methylation is responsible for:

• RNA and DNA (genetic material responsible for every function in the body)
• Immune system regulation
• Detoxification of heavy metals and other harmful substances
• Making GLUTATHIONE (the body’s main detoxification enzyme responsible for removing mercury, lead, cadmium, arsenic, nickel, tin, aluminum and antimony)
• Production and function of proteins
• Regulating inflammation

 What connects B12, methylation, glutathione and Autism Spectrum Disorder?

Short answer:   Dr. S. Jill James (who has recently received a NIH - National Institute of Health - grant for her research) has shown that children with ASD have impaired methylation and decreased levels of glutathione.  Supporting and/or repairing the underlying impairment and deficiency translates into increased social, cognitive and language development.

Long answer: Dr. S. Jill James has also shown that children with ASD have 80% less glutathione in their cells and that 90% of children have defects in their methylation.  This means that children with autism cannot effectively fuel the brain and detoxify heavy metals and other harmful substances from their system. The brain is the only part of the body that has depends entirely on B12 to detoxify.  As the the brain is over-burdened with toxic substances, the “wheels” of methylation slow, severely impacting development. B12 works closely with folic acid. A precursor folic acid molecule must interact with the enzyme MTHFR (methylenetetrahydrofolic acid) to become 5-methyltetrahydrofolic acid (5-MTHF). 5-MTHF gives the methyl group (the “M” part) to B12 so it can become methyl-B12.  Unfortunately, many children have a defect in this enzyme.  In a recent study by Dr. S. Jill James, 90% of children with ASD were found to have methylation defects.

 *In my practice, 92% of children have benefited from MB12 treatment*

 What is the connection between B12 and ADHD?

Dr. Richard Deth is a Ph.D and neuropharmacologist at the Northeastern University.  His area of  research is focused on impaired methylation and oxidative stress in neurological and neuropsychiatric disorders, including autism, ADHD, schizophrenia, and Alzheimer’s disease

Dr. Deth discovered the link between dopamine, methylation and attention which has helped Defeat Autism Now doctors understand why B12 is crucial to treatment of ADHD.  Children with ADHD have difficulty bring methyl inside cells to support methylation and therefore development – especially in the areas of attention and focus.

What are the benefits of MB12 treatment?

Enhancement in executive function:

• Awareness
• Cognition
• Appropriateness
• Eye contact
• Responsiveness
• Normalized behaviors and interaction

Promotion of speech and language:

• Spontaneous language
• More complex sentences
• Increased vocabulary

Improvements in socialization, understanding and expressing emotion:

• Initiation and interactive play
• Understanding and feeling emotions
• Affection and tolerance to touch

 
Undesired effects to B12 therapy are a good sign of treatment success.  They are not uncommon and include:  

• Hyperactivity
• Self Stimulating Behavior
• Increased mouthing of objects
• Sleep disturbances – which can be managed with other treatments
• Aggression, hitting and biting - caused by frustration due to increased awareness 

*Side effects can be mild to severe and are considered transient which means they will pass as  treatment progresses*

 MB12 is a treatment, not a cure.  However, many children using MB12 combined with other biomedical and non-biomedical therapies make incredible developmental gains and in a small percentage of children, have had their ASD label removed

 Parents should understand that the maximum results from MB12 therapy occur over years, not months, not weeks. Initial results will be obvious within the first 3-5 week period of time; but MB12’s power is in continued use.

 Why is MB12 most effective when injected into the bum?

According to Dr. Neubrander , “Only the subcutaneous injectable route of administration into the adipose tissue of the buttocks will produce the remarkable results parents want to see!”

All forms of administration work to some degree, and some better than others. Injection has been shown to be, by far, the most effective route of administration.  It is through injection that the most dramatic strides in development are seen.

MB12 injection into the buttocks area allows MB12 to surround the cells and stay in the system continually.  Oral, transdermal or intranasal forms cause the MB12 levels to fluctuate up and down.  All cobalamins are absorbed in the last portion of the small intestine, the terminal ileum. Dr. Wakefield and Dr. Krigsman and Dr. Buie have shown through their research that an extremely high percentage of children on the autistic spectrum have an inflammatory bowel condition that affects this region of the intestinal tract. This makes injection a better choice than depending on the digestive tract for absorption.

Resource 

More great information about methyal B12 and treating ASD  click  Here

It is very important to know and understand that this comes in a few different forms. Like most vitamins and drugs a more natural version VS Synthetic  Synthetic form of B12 to STAY AWAY from, cyanocobalamin

It is what every pharmacy will spit out and cover, but will actually do more damage then good. Only a COMPOUND Pharmacy is where you will beable to get the correct form of this which is called methylcobalamin.

More information about the B12 forms and differences:HERE   

Methylcobalamin is the form WE use with our B-12 injections. 

I highly recommend to do what we have, and get the proper testing done.             Checking the vitamin B levels and also the MTHFR gene for mutations. Glutathione should be checked as well. Looking for Signs that the body is struggling to methylate and detoxify. 

WHAT Tests do I do? WHO does them? HERES your Answers!  

I have seen great progress with Bella since starting the injections. When we first got our answers to her tests back in May initially I started with the Methyl B-12 folinic nasal spray, as my own issues and PTSD from seeing the needles. I saw no change, and most getting sprayed in was coming out. To me it was a waste of time and money and do not recommend that route. I also researched and learned the best way the body can use and absorb it was through injections ( as it states above) and thus making me face my fears and learn more as to what the injections were and what was in them. Thats when I learned about the different types and how using Compounding pharmacy's take all the useless crap out and use only the real thing and whats needed. Hypoallergenic and preservative FREE. Our insurance does not cover this, it is out of pocket. I am in the mist of fighting to have this as a covered prescription so wish me luck! Everyone has different insurances, and all plans work differently so I DO encourage you to call your own and see if they have a compounding pharmacy they work with, then go from there. This is our newest adventure...isn't Autism fun?! NOT!

Due to Bella's test result her doctor prescribed her injections to contain the methyl B12 , folinic and NAC together. When we started the injections it was the end of June and it was a month of only the B12 ansd folinic together. Then added the NAC started on July 16th. I saw a definite change when the injection was changed to all 3.

Methyl-B12: Doing It Right! Methylcobalamin Update USAAA Semi-annual Conference 

The Folinic acid was added because of its ability to help with the glutathione and cysteine in conjunction with the B12. Just another element to help my bina's body to do what it needs to properly methylate. And NAC was added to help with that plus the fact her amino acids were not working also..all of these work together to help her bodys overall functioning.

What is Folinic Acid? 

FOLINIC ACID, which also is known as5-formyl tetrahydrofolate, is one active form in a group of vitamins known as folates. In contrast to folic acid, a synthetic form of folate, folinic acid is one of the forms of folate found naturally in foods. Folate deficiency is believed to be the most common vitamin deficiency in the world due to food processing, food selection, and intestinal disorders. Folinic acid in the body can be converted into any of the other active forms of folate. Folate coenzymes are responsible for the following important metabolic functions and benefits: 1) Formation of purines and pyrimidines, which in turn are needed for synthesis of the nucleic acids DNA and RNA.  2) Formation of heme, the iron-containing protein in hemoglobin, 3) Interconversion of the 3-carbon amino acid serine from the 2-carbon amino acid glycine, 4) Formation of the amino acids tyrosine from phenylalanine and glutamic acid from histidine, 5) Formation of the amino acid methionine from homocysteine (Vitamin B12 as methylcobalamin also is needed for this conversion). Elevated levels of homocysteine have been implicated in a wide range of health disorders including atherosclerosis, osteoporosis, Alzheimer’s disease, and depression. In the reconversion of homocysteine to methionine the body uses the methionine to make the important amino acid s-adenosylmethionine (SAMe) which is known to be helpful in cases of depression, 6) Synthesis of choline from ethanolamine, 7) Formation and maturation of red and white blood cells, and 8) Conversion of nicotinamide to N’-methylnicotinamide. 

 Efficacy of methylcobalamin and folinic acid treatment on glutathione redox status in children with Autism More Info 

A Folinic Acid Intervention for Autism Spectrum Disorders More info 

 What is NAC?

NAC , N-acetyl-cysteine :

NAC is a slightly modified version of the sulfur-containing amino acid cysteine. When taken internally, NAC replenishes intracellular levels of the natural antioxidant glutathione (GSH), helping to restore cells’ ability to fight damage from reactive oxygen species (ROS).N-acetyl-cysteine NAC’s ability to replenish the intracellular glutathione supply and mitigate oxidative damage is a separate and equally powerful mechanism that affords protection against DNA damage 

N-Acetylcysteine in the Treatment of Childhood Autism NAC shows clinical benefit in autism, as well as other mental health issues 

Antioxidant shows promise as treatment for certain features of autism, study finds - See more 

Mainstream Medicine Investigating "Alternative" N-acetyl cysteine (NAC) For Autism See more

Since we have added this to our protocol, 
I can tell you I am pleased thus far and have seen great gains for my B. She has been noticeably more aware, Has had more spontaneous language and more substance to her communication verbally. 
Example, she started with "knock knock" jokes recently. 
Never before did this. Although the punchline may not be 'funny' it was relevant to what she was saying, and its definitely a good start... 
"knock knock" , 
"who's there?" 
"Hungry" 
"Hungry who?" 
"Mommy I'm hungry can you go get me something to eat?! " 
(then she'd laugh) 
This is a huge for her. 
Also more expressive language and appropriateness in conversation. 
I swear, this is amazing to me the changes , I would NEVER would of been able to have the type of conversations I have had with her 2 years ago that I do today. Reminder.. with ALL things implemented starting in October of 2011. She has truly come such a long way, and in regards to just this B-12 combo injection...WOW , I see such a great gain all around 
that I am super excited to see where all this will go long term!
Also I want to mention Her eye contact has improved, 
cognitively better as well.
She just has surprised me so much with what she has been saying the past few weeks, and its definitely after the NAC added that has this coming out for sure! So it has been working GREAT for my Bella.

As I stated earlier, as a nasal spray, it didn't seam to do much. 
But then the B12/Folinic injections when we first started I did notice  alittle bit hyperactivity but nothing of alarming rates. And after a few injections in, that had subsided. I saw the biggest change though when the NAC was added recently. Alot seam to burst out communicative wise. BUT have also noticed abit more irritability , can it be yeast a brewing? I have read NAC can cause yeast overgrowth so I am trying to keep an eye on that. She has been getting 2 injections a week at our MAPS doc office (the only way our insurance is covering them right now). She is getting more used to them and the anxiety levels of going for her "Pinch to grow an inch" has come down steadily I will be bringing these injections home and administering them myself soon. They are small needles and very quick. I receive them as well and it really don't hurt at all. The anxiety of seeing the injection actually is worse for her then the injection itself. So hopefully I can get the insurance companies to start helping me so I can bring this home, as it will be much more convenient then. 


MORE INFO CLICK HERE: Methyl-B12: A Treatment for ASD with Methylation Issues

Detoxification & Methylation

I hope this information further helps you help your child on your journey to putting your missing pieces back together! God Bless!